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Police are appealing for witnesses after a crash near Anstey.
It happened Friday at around 5.30pm in Cropston Road, between the villages of Cropston and Anstey – near to the junction with Waterfield Road.
The three vehicles reportedly involved were a red Skoda Fabia, a black Range Rover and a van.
The driver of the Fabia, a woman in her 50s, was taken to the Queen’s Medical Centre. She remains in hospital in a serious condition.
The drivers of the other two vehicles did not require hospital treatment.
Detective Constable Louise McMahon from the force’s Serious Collision Investigation Unit, said: “I would like to speak to anyone who witnessed the incident or has dash cam footage of the vehicles either before the collision or of the collision itself.”