There have not been any direct flights since March, which is when the previous airline stopped the route.
Flybe has started daily services between East Midlands and Belfast City airports.
The airline began flights to and from EMA in April when it launched a new service to Amsterdam.
The addition of this route re-establishes the link between the East Midlands and Belfast as there have not been any direct flights since March.
Clare James, East Midlands Airport’s Managing Director, said: “We’re delighted that this popular route is being well-served by flybe. Direct connectivity to Belfast is a boost for this region and the new route provides frequent and easy access to Northern Ireland for people who are visiting for leisure or business. It’s also great news for tourism in the East Midlands and we offer a very warm welcome to visitors who want to explore everything this region has to offer.”
The flight time from East Midlands to Belfast is just over 40 minutes.
Dave Pflieger, flybe’s CEO, said: “We’re overjoyed to be starting flights from East Midlands Airport to Belfast. Our commitment will always be towards offering customers choice whilst providing the great value we’re known for, and we think this is a fantastic route to represent that.
“Connectivity is a priority for us, which is what makes us proud to play a role in tying together these two iconic locations. The new route will be essential to our mission of becoming the number one choice for both regional flights in the UK and between the UK and EU. We’re confident that our flights from East Midlands to Belfast are yet another step towards the future we envision for flybe.”